Following the breaking of the 66 Seals, Sam and Dean are transported away to Ilchester, Maryland. Arriving at Kripke’s Hollow, Zachariah informs Dean that he needs to battle Lucifer. Despite being at odds with one another, Sam and Dean go on the hunt for Lucifer. Soon enough Meg and a possessed Bobby attack Dean in order to stop him in his mission. The scuffle ends with Bobby badly injured and Sam and Dean heading to a lock-up. At this location Zachariah informs Dean that he has to be the vessel for the Archangel Michael. Upon refusing, both Sam and Dean are subdued by Zachariah only to be saved by Castiel. Meanwhile a man named Nick becomes a vessel for Lucifer. Back at the hospital with Bobby, Dean makes an impassioned speech about taking on all angels, demons and Lucifer. Following this, he lets Sam know that he may not be able to trust him ever again.